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Adrenal Fatigue

by Michael Lam, MD, MPH
www.DrLam.com


Contents
Introduction to Adrenal Fatigue Syndrome
Signs and Symptoms of Adrenal Fatigue
Adrenal Gland Basics
Cortisol (Hormone of Death)
Cortisol Regulation
Common Causes of Adrenal Fatigue
How Stressors Affect the Body
Stress Response from a Hormonal Perspective
Adrenal Fatigue Progression
Why Conventional Medicine Missed Adrenal Fatigue
Laboratory Tests
Women and Adrenals
Adrenal Fatigue Protocol
Tips For a Healthy Adrenal Gland
Adrenal Fatigue Recovery
Conclusion

Introduction to Adrenal Fatigue Syndrome

 Adrenal Fatigue Sufferer

Fatigue and lethargy are some of the most common complaints amongst adult patients. If you have symptoms such as tiredness, fearfulness, allergies, frequent influenza, arthritis, anxiety, depression, reduced memory, difficulties in concentrating, insomnia, worn-out, and the inability to lose weight after extensive effort you may be suffering from Adrenal Fatigue (technically known as hypoadrenia).

Adrenal Fatigue has a broad spectrum of non-specific, yet often debilitating symptoms. The onset of this condition is often slow and insidious. Patients are told that they are stressed and need to learn to relax more. Yes, we all know that "stress kills" to a large extent. But, the question is how?

The real truth is that stress and Adrenal Fatigue are not a mysterious entity at all. Our body has a built-in mechanism to deal with it. Being able to handle stress is a key to survival, and the control center in our bodies is the adrenal glands.

Adrenal Fatigue was first described in the medical texts in the 1800's as a clinical condition. It was one of the most prevalent conditions, afflicting almost every adult in one way or another. Despite effective diagnostic tools and treatment programs, most conventional physicians were simply not informed of Adrenal Fatigue and not prepared to take Adrenal Fatigue as a serious threat to health. This condition was seldom diagnosed as a sickness for the past 50 years. Instead, Adrenal Fatigue was considered a condition whereby no treatment was available other than to tell the person to "relax" and take anti-depressants. This often makes the condition worse as the root cause is left unresolved. Over time, the condition worsens as the natural progression of this pathology takes its course. Adrenal Fatigue is not a medical condition recognized by mainstream institutions, though it is now being taken seriously by forward looking physicians.

Adrenal Fatigue should not be confused with another medical condition called Addison's disease where the adrenal glands are not functioning. While Addison's disease is often caused by an auto-immune dysfunction, Adrenal Fatigue is largely caused by stress along with a host of other factors. Adrenal Fatigue is the non-Addison's form of adrenal dysfunction sub-clinically. Unfortunately, conventional medicine only recognizes Addison's disease as hypoadrenia. As such, do not be surprised if your doctor is unfamiliar with this condition.

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For fast reading, scan through the topic headings in BOLD BLACK, important conclusions in BOLD BLUE, and "Must Know" in BOLD RED. To jump to specific sections in this article, click on the respective LINKS in the Contents.

Information presented here is for general educational purposes only. Each one of us is biochemically and metabolically different. If you have a specific health concern and wish my personalized nutritional recommendation, write to me by clicking here.

Signs and Symptoms of Adrenal Fatigue

  • Tendency to gain weight and unable to lose it, especially around the waist.
  • High frequency of getting the flu and other respiratory diseases and these symptoms tend to last longer than usual.
  • Tendency to tremble when under pressure.
  • Reduced sex drive.
  • Lightheaded when rising from a horizontal position.
  • Unable to remember things.
  • Lack of energy in the mornings and in the afternoon between 3 to 5 pm.
  • Feel better suddenly for a brief period after a meal.
  • Often feel tired from 9 - 10 pm, but resist going to bed.
  • Need coffee or stimulants to get going in the morning.
  • Cravings for salty, fatty, and high protein food such as meat and cheese.
  • Increased symptoms of PMS for women; periods are heavy and then stop, or are almost stopped on the 4th day, only to start flow again on the 5th or 6th day.
  • Pain in the upper back or neck with no apparent reason.
  • Feels better when stress is relieved, such as on a vacation.
  • Difficulties in getting up in the morning.
  • Lightheaded.
Other signs and symptoms include:
  • Mild depression
  • Food and or inhalant allergies
  • Lethargy and lack of energy
  • Increased effort to perform daily tasks
  • Decreased ability to handle stress
  • Dry and thin skin
  • Hypoglycemia
  • Low body temperature
  • Nervousness
  • Palpitation
  • Unexplained hair loss
  • Alternating constipation and diarrhea
  • Dyspepsia

If you have many of these signs and symptoms, and you have ruled out other organic pathologies, it is time to consider Adrenal Fatigue as a possible cause. None of the signs or symptoms by themselves can definitively pinpoint Adrenal Fatigue. When taken as a group, these signs and symptoms do form a specific Adrenal Fatigue syndrome or picture of a person under stress. These signs and symptoms are often the end result of acute, severe, chronic, or excessive stress and the inability of the body to reduce such stress. Stress, once a "basket" term used by physicians to explain non-specific symptoms, undetectable by conventional blood tests, is not a mystery to the body at all.

The ability to handle stress, physical or emotional, is a cornerstone to human survival. Our body has a complete set of stress modulation systems in place, and the control center is the adrenal glands. When these glands become dysfunctional, our body's ability to handle stress is reduced.

Adrenal Gland Basics

From our Readers

I am 102 lbs and have been healthy and active until I turned 40 this last March. I have four children and lead a very busy life. A few months before my 40th birthday, I began to shake and feel like I was going to pass out during highly stressful times. My periods, which are usually 28-day cycles, started coming every 21 days. I went to my family Doctor and my OBGYN to see if it was my thyroid or if I was hypoglycemic. They did blood tests and an EKG and said I was the picture of health.

My family doctor thought that I might be suffering from anxiety. My OB doctor was worried about my sugar levels dropping and advised me to always have a little snack with me so I won't pass out. However, I began to feel worse and consequently my period came 3 times a month. I heard about Dr. Lam through a nurse I did yoga with. She had received help from him and felt great with his help. Dr. Lam is an angel! He understood my problem as soon as he understood my medical history, which mostly just consisted of the knowledge that I had my tubes tied after my fourth baby. My doctor said that I would not suffer any consequences from this surgery. However, Dr. Lam informed me that this type of surgery would cause your progesterone to drop, thus explaining my 14 to 21 day periods. He also helped me to understand adrenal gland fatigue, which explained the shaking.

I followed Dr. Lam's advice, using the all-natural personalized program, and thus began my steady ride to recovery. I contacted Dr. Lam the first week in May and he told me that I would begin to feel better in 3 to 4 weeks, good in 6 to 8 weeks, and great in 10 to 12 weeks. He was right on the money. He brought my adrenal glands back to health slowly and steadily and I did not even suffer a crash.

(Read the rest of this testimonial)

Lisa, TX

The adrenal glands are two small glands, each about the size of a large grape. They are situated on top of the kidneys. Their purpose is to help the body cope with stress and help it to survive. Each adrenal gland has two compartments. The inner or medulla compartment, modulates the sympathetic nervous system through secretion and regulation of two hormones, called epinephrine and norepinephrine, which are responsible for the fight or flight response. The outer adrenal cortex comprises 80 percent of the adrenal gland and is responsible for producing over 50 different types of hormones in three major classes - glucocorticoids, mineralcorticoids and androgens.

The most important glucocorticoid is cortisol. When this is lowered, the body will be unable to deal with stress. This happens in Adrenal Fatigue.

Mineralcorticoids, such as aldosterone, modulate the delicate balance of minerals in the cell, especially sodium and potassium. It therefore regulates our blood pressure and the fluid in the body. Stress increases the release of aldosterone, causing sodium retention (leading to water retention and high blood pressure) and the loss of potassium and magnesium in the early stages of Adrenal Fatigue. Magnesium is involved in over 300 enzymatic reactions in the body. When the body lacks magnesium, it will suffer from a variety of pathological conditions such as cardiac arrhythmias.

The adrenal cortex is also responsible for producing all of the sex hormones, although in small amounts. One exception is DHEA, a weak androgenic hormone that is made in large amounts in both sexes. DHEA, together with testosterone and estrogen, are made from pregnenolone.

Pregnenolone also leads to the production of progesterone and is one of the intermediary steps in the making of cortisol. Pregnenolone is therefore one of the most important intermediate hormones being produced in the hormonal cascade. Prolonged deficiencies in pregnenolone, which are found in Adrenal Fatigue, will lead to the reduction of both glucocorticosteroids and mineralcorticoids such as cortisol and aldosterone respectively.

Cortisol (The Hormone of Death)

The most important anti-stress hormone in the body is cortisol. Cortisol protects the body from excessive Adrenal Fatigue by:

  • Normalizing blood sugar level. Cortisol increases the blood sugar level in the body, thus providing the energy needed for the body to physically escape threat of injury in order to survive. Cortisol works in tandem with insulin from the pancreas to provide adequate glucose to the cells for energy. More energy is required when the body is under stress, from any source, and cortisol is the hormone that makes this happen. In Adrenal Fatigue, more cortisol is secreted during the early stages. In the later stages of Adrenal Fatigue (when the adrenal glands become exhausted), cortisol output is reduced.

  • Anti-inflammation Response. Cortisol is a powerful anti-inflammatory agent. When we have a minor injury or a muscle strain, our body's inflammatory cascade is initiated, leading to swelling and redness commonly seen when an ankle is sprained or you have an insect bite. Cortisol is secreted as part of the anti-inflammatory response. It's objective is to remove and prevent swelling and redness of nearly all tissues. These anti-inflammatory responses prevent mosquito bites from enlarging, bronchial stress, and eyes from swelling shut from allergies, and Adrenal Fatigue.

  • Immune System Suppression. People with high cortisol levels are very much weaker from the immunological point of view. Cortisol influences most cells that participate in the immune reaction, especially white blood cells. Cortisol suppresses white blood cells, natural killer cells, monocytes, macrophages, and mast cells. It also suppresses Adrenal Fatigue.

  • Vaso-constriction. Cortisol contracts mid-size arteries. People with low cortisol (as in advance stages of Adrenal Fatigue) have low blood pressure and reduced reactivity to other body agents that constrict blood vessels. Cortisol tends to increase blood pressure that is moderated.

  • Physiology of Stress. People with Adrenal Fatigue cannot tolerate stress and will then succumb to severe stress. As their stress increases, progressively higher levels of cortisol are required. When the cortisol level cannot rise in response to stress, it is impossible to maintain the body in optimum stress response. In this respect, we can conclude that stress does kill.

In summary, cortisol sustains life via two opposite, but related, kinds of regulatory actions: releasing and activating the existing defense mechanisms of the body, while shutting down and modifying the same mechanisms to prevent them.

Cortisol Regulation

The adrenal glands are controlled via the hypothalamus-pituitary-adrenal (HPA) axis. There is an existing negative feedback loop that governs the amount of adrenal hormones secreted under normal circumstances in people with Adrenal Fatigue. For example, the HPA axis adjusts cortisol levels according to the body's need via a hormone called Adrenal Corticotrophic Hormone (ACTH) that is secreted from the pituitary gland in response to signals from the hypothalamus. When the ACTH binds to the walls of the adrenal cells, a chain reaction occurs within the cell. This leads to the release of cholesterol where it is manufactured into pregnenolone, the first hormone in the adrenal cascade. After this, cortisol is released into the blood stream where it travels in the circulatory system to all parts of the body and back to the hypothalamus.

Cortisol and ACTH are not secreted uniformly throughout the day. They follow a diurnal pattern, with the highest level secreted at around 8:00 a.m. in the morning after which there is a gradual decline throughout the day. Episodic spikes during the day can also occur when the body is stressed or when certain foods are taken. The cortisol level is at its lowest between midnight and 4:00 a.m.

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